Phenotypes Associated with This Genotype

Genotype
MGI:5582595

• Allelic Composition: Ryr2^tm2Amks/Ryr2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:212640 )

• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes

• however, a 1,4-benzothiazepine (Rycal S107) prevents calcium leak

atrial fibrillation ( J:212640 )

• induced by atrial burst pacing in 7 of 10 mice

• however, a 1,4-benzothiazepine (Rycal S107) prevents atrial burst pacing-induced atrial fibrillation

muscle

abnormal myocardial fiber morphology ( J:212640 )

• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes

• however, a 1,4-benzothiazepine (Rycal S107) prevents calcium leak

abnormal sarcoplasmic reticulum morphology ( J:212640 )

• leaky calcium channels in the sarcoplasmic reticulum of atrial and, to a lesser extent, ventricular myocytes

• however, a 1,4-benzothiazepine (Rycal S107) prevents calcium leak

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
catecholaminergic polymorphic ventricular tachycardia 1		DOID:0060675	OMIM:604772	J:212640