neoplasm
• 62.5% of mice develop endometrioid tubal tumors in distal and fimbrial parts of the oviduct showing severe nuclear atypia, subnuclear vacuolization, abnormal proliferation, complete loss of normal oviduct architecture and compression of the lumen
• tumors resemble human endometrioid tubal cancer
|
• 27.9% of mice develop endometrioid ovarian tumors which may originate form the endometrioid ovarian cysts, resembling human endometrioid ovarian cancer
|
• 1 of 43 mice develop a granulosa cell tumor which is distinct from the endometrioid tubal cancer
|
reproductive system
• 62.5% of mice develop endometrioid tubal tumors in distal and fimbrial parts of the oviduct showing severe nuclear atypia, subnuclear vacuolization, abnormal proliferation, complete loss of normal oviduct architecture and compression of the lumen
• tumors resemble human endometrioid tubal cancer
|
• 27.9% of mice develop endometrioid ovarian tumors which may originate form the endometrioid ovarian cysts, resembling human endometrioid ovarian cancer
|
• 1 of 43 mice develop a granulosa cell tumor which is distinct from the endometrioid tubal cancer
|
• 9.4% of mice show extraovarian endometrioid lesions within the utero-ovarian ligament, next to the tubal and ovarian tumors
|
ovary cyst
(
J:210095
)
• 16.3% of mice show ovarian endometrioid cysts, mostly in younger mice
|
• 87.2% of mice exhibit tubular intraepithelial lesions in the epithelium of the distal oviduct and fimbriae
• lesions show loss of cilia, bulging of cells into the lumen, layering and suspicious stratification of cells, and rounding and hyperchromatization of the nucleus
• 20% of mice develop glandular transformation of the normal papillary architecture of the oviduct characterized by glandular growth, loss of cilia, and general loss of normal cellular morphology
|
• presence of extraovarian endometrioid lesions coincide with lesions found in the oviduct and ovary
|
endocrine/exocrine glands
• 27.9% of mice develop endometrioid ovarian tumors which may originate form the endometrioid ovarian cysts, resembling human endometrioid ovarian cancer
|
• 1 of 43 mice develop a granulosa cell tumor which is distinct from the endometrioid tubal cancer
|
ovary cyst
(
J:210095
)
• 16.3% of mice show ovarian endometrioid cysts, mostly in younger mice
|
growth/size/body
ovary cyst
(
J:210095
)
• 16.3% of mice show ovarian endometrioid cysts, mostly in younger mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
ovarian cancer | DOID:2394 |
OMIM:167000 OMIM:607893 |
J:210095 |