Phenotypes Associated with This Genotype

Genotype
MGI:5583019

• Allelic Composition: Apc^tm1Rsmi/Apc^tm1Rsmi; Pgr^tm2(cre)Lyd/Pgr⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased reproductive system tumor incidence ( J:210095 )

• 62.5% of mice develop endometrioid tubal tumors in distal and fimbrial parts of the oviduct showing severe nuclear atypia, subnuclear vacuolization, abnormal proliferation, complete loss of normal oviduct architecture and compression of the lumen

• tumors resemble human endometrioid tubal cancer

increased ovary tumor incidence ( J:210095 )

• 27.9% of mice develop endometrioid ovarian tumors which may originate form the endometrioid ovarian cysts, resembling human endometrioid ovarian cancer

increased granulosa cell tumor incidence ( J:210095 )

• 1 of 43 mice develop a granulosa cell tumor which is distinct from the endometrioid tubal cancer

reproductive system

increased reproductive system tumor incidence ( J:210095 )

• 62.5% of mice develop endometrioid tubal tumors in distal and fimbrial parts of the oviduct showing severe nuclear atypia, subnuclear vacuolization, abnormal proliferation, complete loss of normal oviduct architecture and compression of the lumen

• tumors resemble human endometrioid tubal cancer

increased ovary tumor incidence ( J:210095 )

• 27.9% of mice develop endometrioid ovarian tumors which may originate form the endometrioid ovarian cysts, resembling human endometrioid ovarian cancer

increased granulosa cell tumor incidence ( J:210095 )

• 1 of 43 mice develop a granulosa cell tumor which is distinct from the endometrioid tubal cancer

abnormal internal female genitalia morphology ( J:210095 )

• 9.4% of mice show extraovarian endometrioid lesions within the utero-ovarian ligament, next to the tubal and ovarian tumors

ovary cyst ( J:210095 )

• 16.3% of mice show ovarian endometrioid cysts, mostly in younger mice

abnormal oviduct morphology ( J:210095 )

• 87.2% of mice exhibit tubular intraepithelial lesions in the epithelium of the distal oviduct and fimbriae

• lesions show loss of cilia, bulging of cells into the lumen, layering and suspicious stratification of cells, and rounding and hyperchromatization of the nucleus

• 20% of mice develop glandular transformation of the normal papillary architecture of the oviduct characterized by glandular growth, loss of cilia, and general loss of normal cellular morphology

endometrium hyperplasia ( J:210095 )

• presence of extraovarian endometrioid lesions coincide with lesions found in the oviduct and ovary

endocrine/exocrine glands

increased ovary tumor incidence ( J:210095 )

• 27.9% of mice develop endometrioid ovarian tumors which may originate form the endometrioid ovarian cysts, resembling human endometrioid ovarian cancer

increased granulosa cell tumor incidence ( J:210095 )

• 1 of 43 mice develop a granulosa cell tumor which is distinct from the endometrioid tubal cancer

ovary cyst ( J:210095 )

• 16.3% of mice show ovarian endometrioid cysts, mostly in younger mice

growth/size/body

ovary cyst ( J:210095 )

• 16.3% of mice show ovarian endometrioid cysts, mostly in younger mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:210095