cardiovascular system
• the mutant type 2 ryanodine receptor channels show an increase in and widely variable open probability response to luminal calcium compared to wild-type channels which show a moderate response
• however, mice show normal cardiac morphology and functional echocardiogram at rest
|
• hearts under beta-adrenergic stimulation produce more frequent arrhythmic episodes characterized by premature ventricular complexes and ventricular bigeminy
• mice intraperitoneally injected with epinephrine and caffeine show highly arrhythmic behavior, mostly premature ventricular complexes, bigeminy, or ventricular tachyarrhythmias
• optical mapping of the anterior ventricular epicardium following isoproterenol plus caffeine application, indicates multiple ventricular foci of arrhythmia
|
• hearts under beta-adrenergic stimulation produce arrhythmic episodes characterized by premature ventricular complexes
|
• ventricular myocytes subjected to a stress test (isoproterenol-stimulation) exhibit more frequent spontaneous calcium release events and have shorter latency, either partial or fully propagated, than wild-type myocytes
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
catecholaminergic polymorphic ventricular tachycardia 1 | DOID:0060675 |
OMIM:604772 |
J:212870 |