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Phenotypes Associated with This Genotype
Genotype
MGI:5585151
Allelic
Composition		 Agtr2tm1Tin/Y
Efemp2tm1.1Hiya/Efemp2tm1.2Hiya
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr2tm1Tin mutation (0 available); any Agtr2 mutation (11 available)
Efemp2tm1.1Hiya mutation (0 available); any Efemp2 mutation (26 available)
Efemp2tm1.2Hiya mutation (0 available); any Efemp2 mutation (26 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta smooth muscle morphology ( J:213282 )
• hyperproliferation and disarray of aorta smooth muscle cells at 3 months of age
increased aorta wall thickness ( J:213282 )
• the medium of the aortic wall is thicker than in single Agtr2 mutants, with hyperproliferation and disarray of smooth muscle cells at 3 months of age
ascending aorta aneurysm ( J:213282 )
• mice develop aneurysms
• treatment with losartan completely prevents aneurysms

muscle
abnormal aorta smooth muscle morphology ( J:213282 )
• hyperproliferation and disarray of aorta smooth muscle cells at 3 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
aortic aneurysm DOID:3627 J:213282

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory