Analysis Tools
nervous system
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• reactive microglia
• mice exhibit an increase in CD68-positive cells in cortex, thalamus and hippocampus
• cells have a macrophage-like appearance with rounded cell bodies and shortened processes in the cortex, thalamus and hippocampus
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astrocytosis
(
J:213552
)
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• mice exhibit an increase in GFAP immunoreactivity in the cortex, thalamus and hippocampus as compared to controls
• astrocytes throughout the brain appear hypertrophied with enlarged cell soma and thickened processes as compared to controls
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pigmentation
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• autofluorescent storage material is observed in the cortex, thalamus and hippocampus of 5 month old mice
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hematopoietic system
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• reactive microglia
• mice exhibit an increase in CD68-positive cells in cortex, thalamus and hippocampus
• cells have a macrophage-like appearance with rounded cell bodies and shortened processes in the cortex, thalamus and hippocampus
|
immune system
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• reactive microglia
• mice exhibit an increase in CD68-positive cells in cortex, thalamus and hippocampus
• cells have a macrophage-like appearance with rounded cell bodies and shortened processes in the cortex, thalamus and hippocampus
|
behavior/neurological
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• males exhibit decreased exploration, staying in a large Petri dish longer than wild-type mice at 3 and 5 months of age
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• in a modified vertical pole test, 3 and 5 month old mutants climb down on the pole slower and turn downward on the pole slower than wild-type mice
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• 3 month old mutants fall from the rotating rod sooner than wild-type mice, however performance is similar to wild-type mice at 5 months of age
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growth/size/body
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• mice are heavier at 3 months of age, however the weight difference is gone by 5 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| neuronal ceroid lipofuscinosis 1 | DOID:0110721 |
OMIM:256730 |
J:213552 | |
