Phenotypes Associated with This Genotype

Genotype
MGI:5603215

• Allelic Composition: Cdkn2a^tm2Brn/Cdkn2a^tm2Brn; Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased classified tumor incidence ( J:107175 )

• following OHT treatment melanomas are detected in 33% of mice (11 of 33, with 7 pigmented and 4 nonpigmented)

• tumors are often multiple and appear on hairy skin

increased cutaneous melanoma incidence ( J:107175 )

• average pigmented tumor latency is 73 days and mice survive for an average period of 161 days from time of first lesion observation until death

• tumors display the pathologic features of cutaneous spindle-cell melanoma and consist of spindle-shaped melanoma cells and numerous large macrophages loaded with melanin

• tumors are locally invasive with tumor cells found in the lymph nodes

increased neurofibrosarcoma incidence ( J:107175 )

integument

increased cutaneous melanoma incidence ( J:107175 )

• average pigmented tumor latency is 73 days and mice survive for an average period of 161 days from time of first lesion observation until death

• tumors display the pathologic features of cutaneous spindle-cell melanoma and consist of spindle-shaped melanoma cells and numerous large macrophages loaded with melanin

• tumors are locally invasive with tumor cells found in the lymph nodes

nervous system

increased neurofibrosarcoma incidence ( J:107175 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:107175