Phenotypes Associated with This Genotype

Genotype
MGI:5604728

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased endometrial carcinoma incidence ( J:214850 , J:215149 )

♀ • adenocarcinomas (serous and clear cell) show KPNA2 expression while endometrial intraepithelial carcinomas and endometrial glandular dysplasia foci do not exhibit KPNA2 overexpression (J:214850)

♀ • mice show endometrial alterations that progress from normal epithelium to endometrial glandular dysplasia, to endometrial intraepithelial carcinoma, and finally to a papillary adenocarcinoma (J:215149)

♀ • 16 of 19 females at 65-67 weeks of age develop endometrial tumors; three different histological subtypes of type II endometrial carcinomas, as well as carcinosarcomas, develop at high frequency (J:215149)

♀ • individual mice frequently exhibit multiple independent endometrial tumors of different histological appearances (J:215149)

♀ • adenocarcinomas with a papillary growth pattern form exclusively from the surface epithelium of the lumen, whereas those with an acinar growth pattern arise from endometrial glands; both are either serous or clear cell adenocarcinomas (J:215149)

♀ • an intermediate lesion, microinvasive adenocarcinoma, is seen in the glandular compartment of the endometrium (J:215149)

♀ • the lumen surface epithelium also shows sites of endometrial intraepithelial carcinoma with papillary structures lesion characterized by a papillary growth pattern with fibrovascular core (J:215149)

abnormal endometrium morphology ( J:215149 )

♀ • all mice at 24-29 weeks of age show some regions of endometrial glandular dysplasia which are characterized by enlarged and hyperchromatic nuclei, prominent nucleoli, nuclear crowding and loss of basal nuclear localization

abnormal corpus epididymis morphology ( J:215149 )

♂ • regions of the epithelium of the corpus epididymis of males frequently develop a vacuolated appearance and display nuclear atypia at around 6 months of age; these lesions do not progress to tumors

neoplasm

increased endometrial carcinoma incidence ( J:214850 , J:215149 )

♀ • adenocarcinomas (serous and clear cell) show KPNA2 expression while endometrial intraepithelial carcinomas and endometrial glandular dysplasia foci do not exhibit KPNA2 overexpression (J:214850)

♀ • mice show endometrial alterations that progress from normal epithelium to endometrial glandular dysplasia, to endometrial intraepithelial carcinoma, and finally to a papillary adenocarcinoma (J:215149)

♀ • 16 of 19 females at 65-67 weeks of age develop endometrial tumors; three different histological subtypes of type II endometrial carcinomas, as well as carcinosarcomas, develop at high frequency (J:215149)

♀ • individual mice frequently exhibit multiple independent endometrial tumors of different histological appearances (J:215149)

♀ • adenocarcinomas with a papillary growth pattern form exclusively from the surface epithelium of the lumen, whereas those with an acinar growth pattern arise from endometrial glands; both are either serous or clear cell adenocarcinomas (J:215149)

♀ • an intermediate lesion, microinvasive adenocarcinoma, is seen in the glandular compartment of the endometrium (J:215149)

♀ • the lumen surface epithelium also shows sites of endometrial intraepithelial carcinoma with papillary structures lesion characterized by a papillary growth pattern with fibrovascular core (J:215149)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
endometrial cancer		DOID:1380	OMIM:608089	J:214850