Phenotypes Associated with This Genotype

Genotype
MGI:5604887

• Allelic Composition: Tg(MMTV-Erbb2)9Pjo/0
• Genetic Background: involves: BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:72129 )

♀ • 50% of females, but no males, develop mammary tumors after 5-10 months of age

♀ • tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

enlarged seminal vesicle ( J:72129 )

♂ • 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium

hematopoietic system

enlarged spleen ( J:72129 )

♀ • 100% of females, but not males, exhibit splenomegaly

increased spleen red pulp amount ( J:72129 )

♀ • red pulp is hypercellular and composed of immature elements of several lineages

immune system

enlarged spleen ( J:72129 )

♀ • 100% of females, but not males, exhibit splenomegaly

increased spleen red pulp amount ( J:72129 )

♀ • red pulp is hypercellular and composed of immature elements of several lineages

reproductive system

enlarged seminal vesicle ( J:72129 )

♂ • 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium

enlarged epididymis ( J:72129 )

♂ • 100% of males exhibit seminal vesicle and epididymis enlargement; the lumen of the epididymis is often extremely dilated and focal areas of papillary epithelial hyperplasia are seen

reduced male fertility ( J:72129 )

♂ • males are fertile in the first 2 months of age, but most become sterile by 3-4 months

neoplasm

increased mammary adenocarcinoma incidence ( J:72129 )

♀ • 50% of females, but no males, develop mammary tumors after 5-10 months of age

♀ • tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

integument

increased mammary adenocarcinoma incidence ( J:72129 )

♀ • 50% of females, but no males, develop mammary tumors after 5-10 months of age

♀ • tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

growth/size/body

enlarged spleen ( J:72129 )

♀ • 100% of females, but not males, exhibit splenomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:72129