endocrine/exocrine glands
• 33% of males, but no females, develop a salivary gland tumor
|
• 28% of females, but no males, develop mammary tumors after 5-10 months of age
• tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma
|
• 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium
|
hematopoietic system
• 100% of females, but not males, exhibit splenomegaly
|
• red pulp is hypercellular and composed of immature elements of several lineages
|
immune system
• 100% of females, but not males, exhibit splenomegaly
|
• red pulp is hypercellular and composed of immature elements of several lineages
|
reproductive system
• 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium
|
• 100% of males exhibit seminal vesicle and epididymis enlargement; the lumen of the epididymis is often extremely dilated and focal areas of papillary epithelial hyperplasia are seen
|
• males are fertile in the first 2 months of age, but most become sterile by 3-4 months
|
neoplasm
• 33% of males, but no females, develop a salivary gland tumor
|
• 28% of females, but no males, develop mammary tumors after 5-10 months of age
• tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma
|
integument
• 28% of females, but no males, develop mammary tumors after 5-10 months of age
• tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma
|
growth/size/body
• 33% of males, but no females, develop a salivary gland tumor
|
• 100% of females, but not males, exhibit splenomegaly
|
digestive/alimentary system
• 33% of males, but no females, develop a salivary gland tumor
|
craniofacial
• 33% of males, but no females, develop a salivary gland tumor
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
breast cancer | DOID:1612 |
OMIM:114480 |
J:72129 |