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Phenotypes Associated with This Genotype
Genotype
MGI:5605714
Allelic
Composition
Prom1rd19/Prom1rd19
Genetic
Background
B6.BXD83-Prom1rd19/BocJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prom1rd19 mutation (1 available); any Prom1 mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• attenuated retinal vessels by 2 months of age
• at 3 weeks of age there is 20-30% photoreceptor loss with slow progressive loss thereafter
• by 2 months of age homozygotes exhibit areas of depigmentation and attenuated retinal vessels
• at 1 month of age there is a lower ERG a-wave but near normal b-wave, and by six months of age neither cone or rod ERG waveforms are detectable

pigmentation

cardiovascular system
• attenuated retinal vessels by 2 months of age

nervous system
• at 3 weeks of age there is 20-30% photoreceptor loss with slow progressive loss thereafter

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 41 DOID:0110376 OMIM:612095
J:215591


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory