Phenotypes Associated with This Genotype

Genotype
MGI:5605976

cn15

• Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm3.1Wtd; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal involuntary movement ( J:213785 )

limb grasping ( J:213785 )

• forelimb clasping

• action-induced forepaw clenching during tail suspension

dystonia ( J:213785 )

• mice develop spontaneous abnormal movements by second postnatal week

• unilateral twisted hind paw

• bilateral twisted hind paws

• prolonged stiff extension of hind limbs

• abnormal toe postures

• tail extension

tremors ( J:213785 )

impaired coordination ( J:213785 )

• mice exhibit an increase in the number of footslip/cross in beam crossing

abnormal limb posture ( J:288753 )

• 4 of 7 mice show twisted hindpaws at P15

growth/size/body

decreased body size ( J:213785 )

• mice are significantly smaller than littermate controls

postnatal growth retardation ( J:288753 )

• reduced postnatal growth

muscle

dystonia ( J:213785 )

• mice develop spontaneous abnormal movements by second postnatal week

• unilateral twisted hind paw

• bilateral twisted hind paws

• prolonged stiff extension of hind limbs

• abnormal toe postures

• tail extension

nervous system

absent red nucleus ( J:213785 )

• loss of red nucleus by P56

gliosis ( J:213785 , J:288753 )

• minimal gliosis is observed in spinal cord (J:213785)

• reactive gliosis is observed at P56 in deep layers of the sensorimotor cortex, ventral posterior thalamus, globus pallidus, deep cerebellar nuclei, red nucleus and facial nerve nuclei and is less severe than gliosis found in null mice (J:213785)

• reactive gliosis in the cortex and thalamus (J:288753)

neurodegeneration ( J:213785 )

• abnormal accumulation of perinuclear ubiquitin

neuron degeneration ( J:288753 )

• striatal cholinergic interneuron degeneration

vision/eye

narrow eye opening ( J:213785 )

• squinty eyes