Phenotypes Associated with This Genotype

Genotype
MGI:5605977

cn13

• Allelic Composition: En1^tm2(cre)Wrst/En1⁺; Tor1a^tm2Wtd/Tor1a^tm3.1Wtd
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:213785 )

• hindlimb and forelimb clasping observed by P15, however, with maturity clasping decreases

• forepaw clenching during tail suspension observed by P15

dystonia ( J:213785 )

• twisted truncal postures observed by P15, however, mice do not exhibit spontaneous twisting of hind paws

impaired coordination ( J:213785 )

• mice exhibit an increase in number of footslip/cross in beam crossing

muscle

dystonia ( J:213785 )

• twisted truncal postures observed by P15, however, mice do not exhibit spontaneous twisting of hind paws

nervous system

abnormal red nucleus morphology ( J:213785 )

gliosis ( J:213785 )

decreased neuron number ( J:213785 )

• decrease in neuron number in red nucleus and deep cerebellar nuclei (DCN) as compared to controls

• neuron loss in DCN is 2 fold less in this genotype as compared to mice carrying Tor1a^tm1Wtd allele

abnormal facial nerve morphology ( J:213785 )

neurodegeneration ( J:213785 )

• neurodegeneration is milder in in this genotype as compared to mice carrying Tor1a^tm1Wtd allele