Phenotypes Associated with This Genotype

Genotype
MGI:5607532

cx3

• Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺; Lep^ob/Lep^ob
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:180033 )

♂ • mice are less obese than single homozygous Lep^ob mice

homeostasis/metabolism

increased oxygen consumption ( J:180033 )

♂ • oxygen consumption rate is increased and respiratory quotient is lower compared to single homozygous Lep^ob> mice, indicating greater utilization of fat versus carbohydrates as energy source

decreased respiratory quotient ( J:180033 )

♂ • oxygen consumption rate is increased and respiratory quotient is lower compared to single homozygous Lep^ob> mice, indicating greater utilization of fat versus carbohydrates as energy source

improved glucose tolerance ( J:180033 )

♂ • glucose tolerance is ameliorated compared to single homozygous Lep^ob mice

increased insulin sensitivity ( J:180033 )

♂ • insulin sensitivity is ameliorated compared to single homozygous Lep^ob mice

behavior/neurological

behavior/neurological phenotype ( J:180033 )

♂N • no differences in locomotor activity or food intake compared to single homozygous Lep^ob mice