Phenotypes Associated with This Genotype

Genotype
MGI:5617218

• Allelic Composition: Ifih1^Rgsc422/Ifih1^Rgsc422
• Genetic Background: D2JJcl.B6JJcl-Ifih1^Rgsc422

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:209917 )

• rarely survive to 4 weeks of age

postnatal lethality ( J:209917 )

• rarely survive to 4 weeks of age

growth/size/body

postnatal growth retardation ( J:209917 )

immune system

increased susceptibility to systemic lupus erythematosus ( J:209917 )

• develop severe multi-organ autoimmune disease

• inflammation is more severe than in heterozygous mice

glomerulonephritis ( J:209917 )

renal/urinary system

glomerulonephritis ( J:209917 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:209917