integument
N |
• normal coat and whiskers
|
growth/size/body
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
• throughout life
|
• significantly reduced body weight largely due to reduced abdominal fat
|
adipose tissue
craniofacial
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
behavior/neurological
N |
• behavior testing was all done using male mice on a C57BL/6 background
• normal reflexes
• normal activity in an open field test
|
• impaired learning in both context and cue-based tests
|
• increased time spent interacting with a novel inanimate object leading to more normal gooming levels
|
• when alone
|
• poorer coordination displayed on a rotarod test and walking on a horizontal wooden dowel
|
• reduced grip strength displayed by poorer performance in a hanging wire test
|
• increased levels of interaction with a strange mouse
|
nervous system
• significantly reduced neurite length relative to controls after six hours of neuron culture
|
skeleton
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
respiratory system
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
autosomal dominant intellectual developmental disorder | DOID:0060307 |
OMIM:PS156200 |
J:212073 |