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Phenotypes Associated with This Genotype
Genotype
MGI:5617468
Allelic
Composition
Mbd5Gt(Ayu21-B205)Imeg/Mbd5+
Genetic
Background
B6.Cg-Mbd5Gt(Ayu21-B205)Imeg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd5Gt(Ayu21-B205)Imeg mutation (0 available); any Mbd5 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• normal coat and whiskers

growth/size/body
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
• throughout life
• significantly reduced body weight largely due to reduced abdominal fat

adipose tissue

craniofacial
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

behavior/neurological
N
• behavior testing was all done using male mice on a C57BL/6 background
• normal reflexes
• normal activity in an open field test
• impaired learning in both context and cue-based tests
• increased time spent interacting with a novel inanimate object leading to more normal gooming levels
• poorer coordination displayed on a rotarod test and walking on a horizontal wooden dowel
• reduced grip strength displayed by poorer performance in a hanging wire test
• increased levels of interaction with a strange mouse

nervous system
• significantly reduced neurite length relative to controls after six hours of neuron culture

skeleton
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

respiratory system
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200
J:212073


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory