Phenotypes Associated with This Genotype

Genotype
MGI:5617484

hm3

• Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:215209 )

♂ • mice exposed to a cold environment for 8 hours exhibit a higher core body temperature than wild-type mice, indicating enhanced adaptive thermogenesis

increased body temperature ( J:215209 )

♂ • mice exhibit higher body temperature

♂ • however food intake, locomotor activity, respiratory exchange ratio and body weight are normal

increased carbon dioxide production ( J:215209 )

♂ • mice show higher carbon dioxide production at 15 weeks and 8 months of age

♂ • mice show a greater increase in carbon dioxide production in response to treadmill-based exercise than wild-type mice

increased oxygen consumption ( J:215209 )

♂ • mice show increased oxygen consumption at 15 weeks and 8 months of age

♂ • mice show a greater increase in oxygen consumption in response to treadmill-based exercise than wild-type mice