Phenotypes Associated with This Genotype

Genotype
MGI:5617496

• Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn; Tg(Krt18-EGFP,-TAg121)36Ysng/0; Trp53^tm1Brn/Trp53^tm2Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

♀ • 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

♀ • ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated

♀ • mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

increased metastatic potential ( J:189304 )

♀ • distant metastases are seen in the pleura of 87.5%, in the lung of 83% and in the liver of 46% of mutants intrabursally injected with Ad-cre that develop stage IV disease

increased carcinoma incidence ( J:189304 )

♀ • 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

reproductive system

increased ovary tumor incidence ( J:189304 )

♀ • 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

♀ • ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated

♀ • mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

abnormal oviduct morphology ( J:189304 )

♀ • 2% of mice intrabursally injected with Ad-cre exhibit transformation of the oviduct epithelium, with lesions ranging from atypical hyperplasia, to carcinoma in situ to adenocarcinoma

♀ • oviduct lesions are characterized by a glandular/acinar histology

homeostasis/metabolism

hemorrhagic ascites ( J:189304 )

♀ • ovaries in intrabursally Ad-cre injected mice show hemorrhagic or serous ascites

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

♀ • 70% of mice injected with a cre-expressing adenovirus (Ad-cre) under the bursa develop serous epithelial ovarian cancer pathology

increased ovarian carcinoma incidence ( J:189304 )

♀ • ovarian surface epithelium carcinomas that develop in mice intrabursally injected with Ad-cre show a range of morphologic patterns including papillary, micropapillary/filigree, microcystic, poorly differentiated adenocarcinoma, and solid/undifferentiated

♀ • mice develop multifocal peritoneal carcinomatosis with tumor spread to all abdominal organs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304