Phenotypes Associated with This Genotype

Genotype
MGI:5617499

• Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn; Tg(Krt18-EGFP,-TAg121)36Ysng/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovary tumor incidence ( J:189304 )

♀ • 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

reproductive system

increased ovary tumor incidence ( J:189304 )

♀ • 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

endocrine/exocrine glands

increased ovary tumor incidence ( J:189304 )

♀ • 78% of mice injected with a cre-expressing adenovirus under the bursa develop serous epithelial ovarian cancer pathology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:189304