Analysis Tools
behavior/neurological
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• mice bury less marbles than wild-type mice
• however, mice show normal behavior in the social approach test and in the forced swim test
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• mice spend more time in the open arms of the elevated plus-maze and make more entries to the open arms than wild-type mice
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• mice exhibit spontaneous seizures after 5 months of age, with 3 of 12 mice showing seizures at 9 months of age
• seizure behavior includes head bobbing, forelimb and hindlimb clonus that progresses into running and jumping seizures followed by falling and the continuation of head bobbing and forelimb clonus
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• seizures are similar to stage 5 limbic seizures
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growth/size/body
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• mice show decreased body weight that becomes more pronounced with age
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nervous system
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• mice exhibit spontaneous seizures after 5 months of age, with 3 of 12 mice showing seizures at 9 months of age
• seizure behavior includes head bobbing, forelimb and hindlimb clonus that progresses into running and jumping seizures followed by falling and the continuation of head bobbing and forelimb clonus
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• seizures are similar to stage 5 limbic seizures
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | autism spectrum disorder | DOID:0060041 | J:216846 | |
| epilepsy | DOID:1826 | J:216846 | ||
