Phenotypes Associated with This Genotype

Genotype
MGI:5618124

• Allelic Composition: Dicer1^tm1Snj/Dicer1^tm1Snj; Trp53^tm1Brn/Trp53⁺; Tg(KRT5-cre/PGR)1Der/0
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:216813 )

• mean survival is 13 months, with none surviving beyond 18 months

• lethality before 1 year is unrelated to cancer as no tumors are seen until after 1 year of age

integument

increased skin tumor incidence ( J:216813 )

• mice that survive beyond 1 year of age develop skin tumors

• less than 1/4 of mice develop more than a single tumor

increased basal cell carcinoma incidence ( J:216813 )

• mice form mostly basal cell carcinomas

neoplasm

increased skin tumor incidence ( J:216813 )

• mice that survive beyond 1 year of age develop skin tumors

• less than 1/4 of mice develop more than a single tumor

increased basal cell carcinoma incidence ( J:216813 )

• mice form mostly basal cell carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
basal cell carcinoma		DOID:2513		J:216813