Phenotypes Associated with This Genotype

Genotype
MGI:5619354

• Allelic Composition: Rhot1^tm1.1Jmsu/Rhot1^tm1.1Jmsu; Tg(Eno2-cre)39Jme/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:216408 )

• premature death by around P35

growth/size/body

slow postnatal weight gain ( J:216408 )

• mice fail to gain weight with age

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:216408 )

• mice develop severe movement defects with age

limb grasping ( J:216408 )

• mice exhibit hindlimb clasping by P14

abnormal tail movements ( J:216408 )

• mice develop a stiff tail

spasticity ( J:216408 )

• mice develop hind-limb spasticity

nervous system

abnormal brainstem morphology ( J:216408 )

• brainstem and lumbar spinal regions contain aggregate bodies that are not seen in controls, resembling Bunina bodies which are eosinophilic inclusions

• Bunina-like structures appear to be extracellular

skeleton

kyphosis ( J:216408 )

• mice develop kyphosis with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
motor neuron disease		DOID:231		J:216408