Phenotypes Associated with This Genotype

Genotype
MGI:5620891

• Allelic Composition: Lepr^tm1Jke/Lepr^tm1Jke
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:216393 )

• mice become obese at 21-28 days of age

homeostasis/metabolism

hyperglycemia ( J:216393 )

• mice become hyperglycemic between 5 and 10 weeks of age

increased circulating insulin level ( J:216393 )

• mice become hyperinsulinemic at 10-14 days of age

increased liver triglyceride level ( J:216393 )

increased susceptibility to non-insulin-dependent diabetes ( J:216393 )

• mice are diabetic, with high mean glucose concentration despite extreme hyperinsulinemia

liver/biliary system

increased liver triglyceride level ( J:216393 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:216393