Phenotypes Associated with This Genotype

Genotype
MGI:5620953

• Allelic Composition: Tg(Camk2a-Magi2)1Shlee/?
• Genetic Background: C57BL/6J-Tg(Camk2a-Magi2)1Shlee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial working memory ( J:218971 )

♂ • male transgenics exhibit worse spontaneous alternation performance (SAP) in the Y-maze as compared to wild-type and female transgenics

♂ • treatment with LY379268 (metabotropic glutamate receptor type 2/3 agonist) improved spontaneous alternation performance

anhedonia ( J:218971 )

♀ • female transgenics exhibit slightly less sucrose preference as compared to female wild-type mice and male transgenics

increased anxiety-related response ( J:218971 )

♂ • male transgenics spend less time in open arms and more time in closed arms of elevated plus maze as compared to wild-type and female transgenic mice

increased locomotor activity ( J:218971 )

♂ • 3-5 month old male mice travel farther in open field test as compared to wild-type and female transgenics

♂ • clozapine treatment reduces locomotor activity in transgenic, but not wild-type, mice

abnormal social/conspecific interaction behavior ( J:218971 )

♂ • male transgenics do not exhibit a preference for social novelty as compared to wild-type males

abnormal nest building behavior ( J:218971 )

♀ • female transgenics do not form distinguishable nests as compared to nesting behavior observed in wild-type and male transgenics

abnormal social investigation ( J:218971 )

♀ • female mice exhibit less preference for the chamber containing an S1 mouse (three chamber sociability test) than wild-type females

nervous system

abnormal brain interneuron morphology ( J:218971 )

• reduced numbers of parvalbumin+ GABAergic interneurons (basket and chandelier cells) in the stratum pyramidal layer of hippocompal CA1 and CA3 layers

• reduced numbers of parvalbumin+ interneurons in layers III and V of the somatosensory cortex

enlarged lateral ventricles ( J:218971 )

• enlarged lateral ventricle (1.5 fold increase as compared to wild-type)

• males exhibit greater variability in size than do females

abnormal dendritic spine morphology ( J:218971 )

• decrease in dendritic spine densities of CA1 and CA3 neurons

• decrease in dendritic spine densities in neurons from layer III of the somatosensory cortices

abnormal excitatory postsynaptic potential ( J:218971 )

• 3-4 month old mice exhibit increased AMPAR-mediated fEPSPs in the stratum radiatum at all stimulation intensities

• male mice exhibit a greater increase of fEPSPs than females

reduced long-term potentiation ( J:218971 )

♂ • male transgenic mice have reduced hippocampal LTP induced by two trains of high-frequency stimulation

decreased prepulse inhibition ( J:218971 )

• mice of both sexes exhibit deficits in PPI

• clozapine treatment restores PPI at pre pulse levels of 77 and 82 dB in male mice and at all levels in female mice

taste/olfaction

abnormal sweet taste sensitivity ( J:218971 )

♀ • female transgenics exhibit slightly less sucrose preference as compared to female wild-type mice and male transgenics

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:218971