Phenotypes Associated with This Genotype

Genotype
MGI:5621175

• Allelic Composition: Tg(SOD1)2Gur/0; Tg(SOD1*)D-14Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hindlimb paralysis ( J:218091 )

• mice develop hindlimb paralysis between 12 and 20 months of age

nervous system

abnormal motor neuron morphology ( J:218091 )

• within surviving motor neurons, wispy fibrillar ubiquitin, mutant SOD1, and Thioflavin S positive inclusions are seen that do not contain wild-type SOD1

motor neuron degeneration ( J:218091 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:218091