Phenotypes Associated with This Genotype

Genotype
MGI:5629689

• Allelic Composition: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0; Tg(Prnp-MAPT*P301S)PS19Vle/0
• Genetic Background: B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:211723 )

• mice develop extracellular amyloid plaque to a similar extent as mice expressing only the Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas trasngene

nervous system

amyloid beta deposits ( J:211723 )

• mice develop extracellular amyloid plaque to a similar extent as mice expressing only the Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas trasngene

abnormal hippocampus morphology ( J:211723 )

• mice show aggravation of hyperphosphorylated tau pathology that is already seen at 3 months of age

abnormal hippocampal mossy fiber morphology ( J:211723 )

• mossy fiber degeneration by 9 months of age

hippocampal neuron degeneration ( J:211723 )

loss of hippocampal neurons ( J:211723 )

• mice show reduced number of CA1 neurons at 9 months of age compared to either single mutant, indicating increased loss of hippocampal CA1 neurons

hippocampus atrophy ( J:211723 )

• hippocampal atrophy in aged mice

astrocytosis ( J:211723 )

• mice show increased astrocytosis in the cortex and thalamus at 3 months of age, and by 9 months of age, astrocytosis is strongly elevated in the hippocampus

abnormal dendrite morphology ( J:211723 )

• aged mice show a decrease in apical dendrite density in the hippocampal stratum radiatum

abnormal synapse morphology ( J:211723 )

• increase in loss of synapses

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:211723