Phenotypes Associated with This Genotype

Genotype
MGI:5630054

• Allelic Composition: Itpr2^tm1Kmik/Itpr2^tm1Kmik
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal sweat gland physiology ( J:217699 )

• sweat glands show a 40-50% reduction in amplitude of calcium signals in response to stimulation with acetylcholine

hypohidrosis ( J:217699 )

• injection of pilocarpine into the hind paws to induce a sweat response shows that the increase in sweat gland number that is seen in wild-type mice with time is attenuated and sweat volume is decreased

integument

abnormal sweat gland physiology ( J:217699 )

• sweat glands show a 40-50% reduction in amplitude of calcium signals in response to stimulation with acetylcholine

hypohidrosis ( J:217699 )

• injection of pilocarpine into the hind paws to induce a sweat response shows that the increase in sweat gland number that is seen in wild-type mice with time is attenuated and sweat volume is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated anhidrosis with normal sweat glands		DOID:0060603	OMIM:106190	J:217699