Phenotypes Associated with This Genotype

Genotype
MGI:5632308

• Allelic Composition: Nrxn2^tm1Sud/Nrxn2^tm1Sud
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * C57BL/6NClr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:220076 )

• in the open field, mutants spend more time in the peripheral zone near the walls and less time in the intermediate zone, than wild-type mice, however the total distance traveled is not different

• in the elevated plus maze, mutants spend less time in the open arms and more time in the closed arms, make fewer exploratory head dips from the center and open arms, and spend less time on the central square

• in the emergence test, mutants take 3.7 times longer than wild-type mice to emerge from a small enclosure, spend more time in the enclosure and make fewer entries into the open arena

• mutants exhibit normal behavior in the Porsolt forced-swim test and tail suspension test, indicating absence of depression-related behaviors

• mice exhibit normal long term memory in passive avoidance learning

abnormal response to novel object ( J:220076 )

• in the novel object test, mutants spend les time exploring a novel object than wild-type mice, however locomotor activity is normal during both habituation and test phases

increased vertical activity ( J:220076 )

• mutants spend more time rearing than wild-type mice, however no differences in the time spent self-grooming is seen

abnormal social investigation ( J:220076 )

• in the three-chambered assay for sociability, mutants fail to show a preference for the unfamiliar conspecific, however mutants spend an equivalent amount of time in proximity to the empty cage as wild-type mice

• in a social novelty preference test with a choice between the original unfamiliar mouse and a new unfamiliar mouse, mutants do not exhibit a preference for the new unfamiliar mouse as seen in wild-type mice

• in a test of preference for exploring soiled versus clean bedding in the three-chambered assay, mutants show no bias towards either cage unlike wild-type mice which spend more time in the soiled bedding cage, however mutants exhibit a similar latency to find buried food as wild-type mice, indicating normal olfaction

nervous system

nervous system phenotype ( J:220076 )

N • mice show normal startle responses to varying intensities of sound and normal magnitudes of prepulse inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:220076