Phenotypes Associated with This Genotype

Genotype
MGI:5634332

• Allelic Composition: Tg(Eno2-APP*Ind)#Kakiz/Tg(Eno2-APP*Ind)#Kakiz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:212692 )

• 9 month old mice show impairment in spatial memory in the Morris water maze, needing more time to reach the hidden platform

• mice, however do not exhibit differences in basal activities up to 18 months of age

• oral administration of hop flower extract improves spatial memory

decreased anxiety-related response ( J:212692 )

• at 18 months of age, mutants show longer times away form the walls in the open field, indicating impairment in feeling anxiety

• oral administration of hop flower extract prevents the disturbance seen in the open field

homeostasis/metabolism

amyloid beta deposits ( J:212692 )

• amyloid beta deposits are seen in the parietal lobe of the cerebral cortex

• oral administration of hop flower extract reduces amyloid beta deposits

cerebral amyloid angiopathy ( J:212692 )

• amyloid angiopathy is seen around certain artery walls

nervous system

amyloid beta deposits ( J:212692 )

• amyloid beta deposits are seen in the parietal lobe of the cerebral cortex

• oral administration of hop flower extract reduces amyloid beta deposits

cerebral amyloid angiopathy ( J:212692 )

• amyloid angiopathy is seen around certain artery walls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:212692