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Phenotypes Associated with This Genotype
Genotype
MGI:5634707
cn3
Allelic
Composition		 Il1r1tm1Quan/Il1r1tm1Quan
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1tm1Quan mutation (1 available); any Il1r1 mutation (39 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal microglial cell activation ( J:219864 )
• microglia are activated (deramified) throughout the brain prenchyma following IL1beta injection

immune system
abnormal microglial cell activation ( J:219864 )
• microglia are activated (deramified) throughout the brain prenchyma following IL1beta injection
abnormal inflammatory response ( J:219864 )
• intracerebroventricular IL1beta administration results in leukocyte infiltration (CD45+ cell trafficking) to the brain parenchyma 12 hours after injection

nervous system
abnormal microglial cell activation ( J:219864 )
• microglia are activated (deramified) throughout the brain prenchyma following IL1beta injection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory