Phenotypes Associated with This Genotype

Genotype
MGI:5634972

• Allelic Composition: Per1^tm1Drw/Per1^tm1Drw
• Genetic Background: B6.129-Per1^tm1Drw/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:219876 )

• mice exhibit impaired learning and memory in the Morris water maze

abnormal impulsive behavior control ( J:219876 )

• mice are impulsive in the open-field

increased vertical activity ( J:219876 )

increased locomotor activity ( J:219876 )

• mice are hyperactive and impulsive in the open-field, traveling a longer distance in 5 min, and showing an increase in the number of line crossings

homeostasis/metabolism

decreased dopamine level ( J:219876 )

♀ • brain dopamine levels are lower in females, but not males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:219876