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Phenotypes Associated with This Genotype
Genotype
MGI:5636486
Allelic
Composition
Tg(Th-ALK*F1174L)2Loch/0
Tg(Th-MYCN)41Waw/0
Genetic
Background
involves: 129X1/SvJ * BALB/c * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-ALK*F1174L)2Loch mutation (0 available)
Tg(Th-MYCN)41Waw mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop large, bulky and locally invasive thoracic and abdominal masses arising in the paraspinal ganglia or adrenals indicative of neuroblastoma
• mice show complete tumor penetrance, shorter median time to tumor onset and decreased survival at 100 days of age compared to single Tg(Th-MYCN)41Waw hemizygous mice
• tumors show decreased level of apoptosis compared to tumors from single Tg(Th-MYCN)41Waw hemizygous mice
• mice are resistant to crizotinib treatment, showing no effect on tumor size, cellularity or apoptosis
• combined treatment with crizotinib and Torin2 (an ATP-competitive inhibitor of mTOR) reduces tumor size and growth and increases apoptosis

mortality/aging
• mice show decreased survival at 100 days of age

nervous system
• mice develop large, bulky and locally invasive thoracic and abdominal masses arising in the paraspinal ganglia or adrenals indicative of neuroblastoma
• mice show complete tumor penetrance, shorter median time to tumor onset and decreased survival at 100 days of age compared to single Tg(Th-MYCN)41Waw hemizygous mice
• tumors show decreased level of apoptosis compared to tumors from single Tg(Th-MYCN)41Waw hemizygous mice
• mice are resistant to crizotinib treatment, showing no effect on tumor size, cellularity or apoptosis
• combined treatment with crizotinib and Torin2 (an ATP-competitive inhibitor of mTOR) reduces tumor size and growth and increases apoptosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:191012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory