Phenotypes Associated with This Genotype

Genotype
MGI:5636650

• Allelic Composition: Tg(Lck-Tax)53Hall/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:129531 )

• mice develop diffuse, large-cell lymphomas involving spleen, lymph nodes, liver, thymus, bone marrow, kidney, lung, meninges and skin

• perivascular infiltration of lymphomatous cells are seen in the liver, kidney, and lungs

increased leukemia incidence ( J:129531 )

• presence of large and abnormal leukemic cells with cleaved nuclei identical to flower cells seen in adult T-cell leukemia-lymphoma (ATLL)

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:129531 )

• mice develop diffuse, large-cell lymphomas involving spleen, lymph nodes, liver, thymus, bone marrow, kidney, lung, meninges and skin

• perivascular infiltration of lymphomatous cells are seen in the liver, kidney, and lungs

growth/size/body

enlarged liver ( J:129531 )

• mice develop hepatomegaly beginning at 10 months of age

enlarged spleen ( J:129531 )

• mice develop splenomegaly beginning at 10 months of age

hepatosplenomegaly ( J:129531 )

• hepatosplenomegaly with a 5-20-fold increase in organ size

immune system

increased T cell derived lymphoma incidence ( J:129531 )

• mice develop diffuse, large-cell lymphomas involving spleen, lymph nodes, liver, thymus, bone marrow, kidney, lung, meninges and skin

• perivascular infiltration of lymphomatous cells are seen in the liver, kidney, and lungs

enlarged spleen ( J:129531 )

• mice develop splenomegaly beginning at 10 months of age

hepatosplenomegaly ( J:129531 )

• hepatosplenomegaly with a 5-20-fold increase in organ size

enlarged lymph nodes ( J:129531 )

• mice develop lymphadenopathy beginning at 10 months of age

• lymphadenopathy is most often seen in the mesenteric, cervical and axillary lymph nodes and sometimes inguinal nodes

increased susceptibility to fungal infection ( J:129531 )

• mice develop severe pulmonary infections with P.jiroveci

liver/biliary system

enlarged liver ( J:129531 )

• mice develop hepatomegaly beginning at 10 months of age

hepatosplenomegaly ( J:129531 )

• hepatosplenomegaly with a 5-20-fold increase in organ size

hematopoietic system

increased T cell derived lymphoma incidence ( J:129531 )

• mice develop diffuse, large-cell lymphomas involving spleen, lymph nodes, liver, thymus, bone marrow, kidney, lung, meninges and skin

• perivascular infiltration of lymphomatous cells are seen in the liver, kidney, and lungs

enlarged spleen ( J:129531 )

• mice develop splenomegaly beginning at 10 months of age

hepatosplenomegaly ( J:129531 )

• hepatosplenomegaly with a 5-20-fold increase in organ size

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell adult acute lymphocytic leukemia		DOID:5602		J:129531 , J:214623