Analysis Tools
mortality/aging
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• mice die by 15 months of age
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hematopoietic system
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• abnormal lymphoid development in aging mice
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• 8-13 month old mice show defects in the generation of immature B/pre-B cells
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• 8-13 month old mice show defects in the generation of pro-B cells
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• decrease in the relative frequency of CD4/CD8 double-positive cells in 8-13 month old mice
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• macrocytic anemia appears as early as 6 months of age and progressively worsens
• transplantation of mutant marrow into wild-type recipients recapitulates age-related macrocytic anemia, lymphopenia, and megaloblastic changes
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• mice become lymphopenic by 8 months of age, involving both major lymphoid lineages
• however, mice do not develop leukocytosis or signs of leukemic conversion
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• decrease in total viable thymocytes in 8-13 month old mice
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• bone marrow of 8-13 month old mice shows a decrease in mature B cells
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• 8-13 month old mice show defects in the generation of immature B/pre-B cells
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• abnormal erythroid development in aging mice
• 8 month old mice exhibit an increase in the frequency of Ter119+ splenocytes, with a significant expansion in both polychromatophilic normoblasts and reticulocytes
• 10 month old splenocytes exhibit stress erythropoiesis, with a significant increase in frequency of polychromatophilic normoblasts
• in the bone marrow of 10 month old mice, an expansion of polychormatophilic normoblasts is seen at the expense of both reticulocytes and mature red blood cells
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• 8 and 10 month old splenocytes and 10 month old bone marrow show an increase in the frequency of polychromatophilic normoblasts
• a population of erythroblasts characterized by intermediate cell size and low-to-negative expression of CD71 is expanded in the bone marrow of 10 month old mice; this population of orthochromic erythroblasts has abundant, fully hemoglobinized cytoplasm, indicating megoblastic morphologic changes
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• from 6 to 10 months of age, hemoglobin levels are moderately decreased and from 11 months onward, hemoglobin levels rapidly decrease
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• mean corpuscular volume of reticulocytes increases sharply from 8 months of age
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macrocytosis
(
J:154187
)
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• macrocytosis becomes evident after 8 months of age, shortly after development of anemia, and worsens with age
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cellular
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• as early as 4 months of age, a decreased cytochrome oxidase/citrate synthase ratio is seen in mitochondria of the spleen and this ratio is decreased in both spleen and liver mitochondria at 9-10 months of age, indicating mitochondrial dysfunction
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endocrine/exocrine glands
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• decrease in total viable thymocytes in 8-13 month old mice
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immune system
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• abnormal lymphoid development in aging mice
|
|
• 8-13 month old mice show defects in the generation of immature B/pre-B cells
|
|
• 8-13 month old mice show defects in the generation of pro-B cells
|
|
• decrease in the relative frequency of CD4/CD8 double-positive cells in 8-13 month old mice
|
|
• mice become lymphopenic by 8 months of age, involving both major lymphoid lineages
• however, mice do not develop leukocytosis or signs of leukemic conversion
|
|
• decrease in total viable thymocytes in 8-13 month old mice
|
|
• bone marrow of 8-13 month old mice shows a decrease in mature B cells
|
|
• 8-13 month old mice show defects in the generation of immature B/pre-B cells
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| myelodysplastic syndrome | DOID:0050908 |
OMIM:614286 |
J:154187 | |
