Phenotypes Associated with This Genotype

Genotype
MGI:5637429

• Allelic Composition: Hbb-b1^tm1Unc/Hbb-b1⁺; Hbb-b2^tm1Unc/Hbb-b2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:97548 )

abnormal erythropoiesis ( J:97548 )

• active but ineffective erythropoiesis and hemolysis

anemia ( J:154187 )

• anemia is associated with a stress erythropoietic response characterized by an expansion of polychromatophilic normoblasts and reticulocytes in both marrow and spleen

increased erythroblast number ( J:154187 )

• expansion of polychromatophilic normoblasts in both marrow and spleen

decreased erythrocyte cell number ( J:97548 )

decreased hematocrit ( J:97548 )

decreased hemoglobin content ( J:97548 )

decreased mean corpuscular volume ( J:97548 )

increased red blood cell distribution width ( J:97548 )

abnormal reticulocyte cell number ( J:154187 )

• expansion of reticulocytes in both marrow and spleen

reticulocytosis ( J:97548 )

homeostasis/metabolism

increased circulating bilirubin level ( J:97548 )

immune system

enlarged spleen ( J:97548 )

growth/size/body

enlarged spleen ( J:97548 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:154187