Analysis Tools
neoplasm
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• high-grade mammary carcinomas with both inter- and intra-tumor heterogeneity, with features of both luminal and basal subtypes
• tumors are of high grade, solid morphology and express varying levels of estrogen receptor alpha
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• multiparous mice develop mammary tumors with 80% penetrance and a median latency of 314 days
• however, no tumors are seen in nulliparous mice up to 2 years of age and nulliparous mice do not show increased Espl1 expression as is seen in multiparous mice
• four types of mammary tumors are seen; spindle-like, solid, glandular, and squamous
• mice develop regions of carcinosarcomas or epithelial-to-mesenchymal transition (EMT) tumors
• rapid tumor progression is due to increased early cellular proliferation coupled with accumulation of DNA damage
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cellular
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• chromosomes in transgene expressing cells are thinner
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aneuploidy
(
J:216267
)
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• mice progressively accumulate aneuploidy in the parous mammary epithelia and tumors show aneuploidy
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• genomic instability accumulates in mammary epithelial cells of mutants before tumorigenesis
• mammary epithelial cell cultures at passage 0 from multiparous mice show an increase in micro-nuclei, multinucleated cells, chromosome bridges, and aberrant numbers of centrosomes
• mammary epithelial cells from parous mice show a 34% increase in premature sister chromatid separation
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endocrine/exocrine glands
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• at 6 months of age, post lactating mammary glands of females weaned on day 1 have delayed involution compared to wild-type females
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• high-grade mammary carcinomas with both inter- and intra-tumor heterogeneity, with features of both luminal and basal subtypes
• tumors are of high grade, solid morphology and express varying levels of estrogen receptor alpha
|
|
|
• multiparous mice develop mammary tumors with 80% penetrance and a median latency of 314 days
• however, no tumors are seen in nulliparous mice up to 2 years of age and nulliparous mice do not show increased Espl1 expression as is seen in multiparous mice
• four types of mammary tumors are seen; spindle-like, solid, glandular, and squamous
• mice develop regions of carcinosarcomas or epithelial-to-mesenchymal transition (EMT) tumors
• rapid tumor progression is due to increased early cellular proliferation coupled with accumulation of DNA damage
|
|
|
• at 6 months of age, post lactating mammary glands of females weaned on day 1 appear severely hyperplastic
• at 12 months of age, mice develop small masses of mammary hyperplasia, large amounts of immune reaction, and presence of hyperproliferative stroma
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integument
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• at 6 months of age, post lactating mammary glands of females weaned on day 1 have delayed involution compared to wild-type females
|
|
|
• high-grade mammary carcinomas with both inter- and intra-tumor heterogeneity, with features of both luminal and basal subtypes
• tumors are of high grade, solid morphology and express varying levels of estrogen receptor alpha
|
|
|
• multiparous mice develop mammary tumors with 80% penetrance and a median latency of 314 days
• however, no tumors are seen in nulliparous mice up to 2 years of age and nulliparous mice do not show increased Espl1 expression as is seen in multiparous mice
• four types of mammary tumors are seen; spindle-like, solid, glandular, and squamous
• mice develop regions of carcinosarcomas or epithelial-to-mesenchymal transition (EMT) tumors
• rapid tumor progression is due to increased early cellular proliferation coupled with accumulation of DNA damage
|
|
|
• at 6 months of age, post lactating mammary glands of females weaned on day 1 appear severely hyperplastic
• at 12 months of age, mice develop small masses of mammary hyperplasia, large amounts of immune reaction, and presence of hyperproliferative stroma
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| breast cancer | DOID:1612 |
OMIM:114480 |
J:216267 | |
