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Phenotypes Associated with This Genotype
Genotype
MGI:5637746
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(GRN)Pvd/Gt(ROSA)26Sortm1(GRN)Pvd
Tg(Pgk1-cre)1Lni/0
Tg(SOD1*G93A)1Gur/0
Genetic
Background
B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sortm1(GRN)Pvd Tg(SOD1*G93A)1Gur
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(GRN)Pvd mutation (0 available); any Gt(ROSA)26Sor mutation (1026 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average lifespan is 168.4 days

nervous system
• onset or progression of motor neuron degeneration is similar to that seen in mice expressing only Tg(SOD1*G93A)1Gur, with an average onset of disease at 138.2 days

behavior/neurological
• mice show impaired performance on the rotarod and in hanging from a grid to a similar extent as seen in mice expressing only Tg(SOD1*G93A)1Gur


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory