Phenotypes Associated with This Genotype

Genotype
MGI:5638045

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Scrib^tm1.1Phum/Scrib^tm1.1Phum
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:216266 )

• 100% of mice develop lung lesions at 6 weeks post intranasal adenoviral cre (AdCre) administration, ranging from grades 1 to 3

• mice show accelerated lung tumorigenesis, with more advanced and higher-grade tumors post intranasal AdCre administration compared to single Kras heterozygotes

• a 2.9-fold increase in tumor burden compared to single Kras heterozygotes at 12 weeks post intranasal AdCre administration

• lung tumors from intranasally AdCre treated mice show enhanced stromal reactivity and inflammation

respiratory system

increased lung tumor incidence ( J:216266 )

• 100% of mice develop lung lesions at 6 weeks post intranasal adenoviral cre (AdCre) administration, ranging from grades 1 to 3

• mice show accelerated lung tumorigenesis, with more advanced and higher-grade tumors post intranasal AdCre administration compared to single Kras heterozygotes

• a 2.9-fold increase in tumor burden compared to single Kras heterozygotes at 12 weeks post intranasal AdCre administration

• lung tumors from intranasally AdCre treated mice show enhanced stromal reactivity and inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:216266