Phenotypes Associated with This Genotype

Genotype
MGI:5638047

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Scrib^tm1.1Phum/Scrib⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:216266 )

• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration

respiratory system

increased lung tumor incidence ( J:216266 )

• 83% of mice develop tumors ranging from grades 1 to 3 at 6 weeks post intranasal adenoviral cre (AdCre) administration

lung epithelium hyperplasia ( J:216266 )

• 100% of mice show epithelial hyperplasia at 6 weeks post intranasal AdCre administration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:216266