Phenotypes Associated with This Genotype

Genotype
MGI:5638106

• Allelic Composition: Cd3e^tm1Mal/Cd3e^tm1Mal; Tg(Tcrb-TCF3/PBX1)23Gusa/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:95693 )

• leukemia tumor development penetrance is 87%

• mice intraperitonally injected with MMLV show accelerated pre-B-cell leukemia formation compared to controls

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 40% of mice develop B-cell acute lymphoblastic leukemia

• however, mice do not develop T-cell acute lymphoblastic leukemia, myeloid leukemia, or mixed B-cell/myeloid leukemia

• B-cell leukemia development is accelerated compared to single Tg(Tcrb-TCF3/PBX1)23Gusa transgenic mice

• B-cell tumors are B220+/CD43-/CD19+/IgM-/Pax5+, indicating a pre-B-cell phenotype, and contain IgH chain rearrangements, mostly of the kappa light chain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute leukemia		DOID:12603	OMIM:308960	J:95693