neoplasm
• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5
• tumors resemble Wilms tumor
• mice treated with doxycycline at P10 do not develop tumors
|
renal/urinary system
kidney cyst
(
J:211179
)
• mice treated with doxycycline at P10 develop cystic kidneys
|
• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5
• tumors resemble Wilms tumor
• mice treated with doxycycline at P10 do not develop tumors
|
• doxycycline induced mice exhibit persistent proliferation of cap mesenchyme cells in adults
• however, cap mesenchyme cells within tumors retain a differentiation capacity that recapitulates normal kidney development
|
• timing of kidney development is prolonged in doxycycline induced mice, with sustaining proliferation of the cap mesenchyme cells into adulthood
|
growth/size/body
kidney cyst
(
J:211179
)
• mice treated with doxycycline at P10 develop cystic kidneys
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
nephroblastoma | DOID:2154 |
OMIM:194070 |
J:211179 |