Phenotypes Associated with This Genotype

Genotype
MGI:5638793

• Allelic Composition: Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺; Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased kidney tumor incidence ( J:211179 )

• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5

• tumors resemble Wilms tumor

• mice treated with doxycycline at P10 do not develop tumors

renal/urinary system

kidney cyst ( J:211179 )

• mice treated with doxycycline at P10 develop cystic kidneys

increased kidney tumor incidence ( J:211179 )

• mice treated with doxycycline at P10 do not develop tumors

• all mice develop kidney tumors within the first 2 weeks of life following doxycycline (Dox) induction during embryonic development at E0, E14.5 or E18.5

• tumors resemble Wilms tumor

abnormal kidney mesenchyme morphology ( J:211179 )

• doxycycline induced mice exhibit persistent proliferation of cap mesenchyme cells in adults

• however, cap mesenchyme cells within tumors retain a differentiation capacity that recapitulates normal kidney development

delayed kidney development ( J:211179 )

• timing of kidney development is prolonged in doxycycline induced mice, with sustaining proliferation of the cap mesenchyme cells into adulthood

growth/size/body

kidney cyst ( J:211179 )

• mice treated with doxycycline at P10 develop cystic kidneys

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephroblastoma		DOID:2154	OMIM:194070	J:211179