Phenotypes for Commd10 Jak2 Picalm MGI:5640746 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Jak2^tm1.2Ble/Jak2⁺ Picalm^tm1.1Tmae/Picalm⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Jak2^tm1.2Ble mutation (0 available); any Jak2 mutation (59 available)
Picalm^tm1.1Tmae mutation (1 available); any Picalm mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:220728 )

• increased red blood cell counts

increased hematocrit ( J:220728 )

• high hematocrit

increased hemoglobin content ( J:220728 )

decreased mean corpuscular hemoglobin ( J:220728 )

decreased mean corpuscular volume ( J:220728 )

thrombocytosis ( J:220728 )

• mild thrombocytosis

reticulocytosis ( J:220728 )

• elevated reticulocyte counts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycythemia vera		DOID:8997	OMIM:263300	J:220728

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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