Phenotypes Associated with This Genotype

Genotype
MGI:5641392

• Allelic Composition: Tsc1^tm1Hin/Tsc1⁺
• Genetic Background: B6J.129S4-Tsc1^tm1Hin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:221239 )

♂ • males spend less time in the dark chamber of the light/dark box, suggesting low anxiety

hyporesponsive to tactile stimuli ( J:221239 )

♂ • in the tail flick test, males have a longer latencies than females

increased vertical activity ( J:221239 )

• increase in rearing behavior

• treatment with rapamycin attenuates rearing behavior

abnormal social investigation ( J:221239 )

• mice spend a shorter time engaged in active interaction with a novel mouse than wild-type mice

• however, mice are not altered in social dominance, exhibit normal olfaction and exploration towards an inanimate object, and show intact motor and sensory function

• treatment with rapamycin extends the time of active interaction with a novel mouse

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:221239
tuberous sclerosis		DOID:13515	OMIM:PS191100	J:221239