Phenotypes Associated with This Genotype

Genotype
MGI:5641393

• Allelic Composition: Tsc2^tm1Tno/Tsc2⁺
• Genetic Background: B6J.129S4-Tsc2^tm1Tno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased coping response ( J:221239 )

• immobility time in the tail suspension test is longer than in wild-type mice

• however, in the light/dark box test, time spend in the dark compartment is not different

increased vertical activity ( J:221239 )

• increase in rearing behavior

• treatment with rapamycin attenuates rearing behavior

abnormal social investigation ( J:221239 )

• mice spend a shorter time engaged in active interaction with a novel mouse than wild-type mice

• however, mice are not altered in social dominance, exhibit normal olfaction and exploration towards an inanimate object, and show intact motor and sensory function

• treatment with rapamycin extends the time of active interaction with a novel mouse

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:221239
tuberous sclerosis		DOID:13515	OMIM:PS191100	J:221239