Analysis Tools
reproductive system
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• mice exhibit myometrial overgrowth, developing tumors consistent with leiomyomas by 24 weeks of age
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• increase in endometrial proliferation, with more endometrial glands and irregular luminal epithelium in uteri
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• increase in myometrial proliferation at 12 weeks of age
• myometrium is thickened with rough borders and irregular, disoriented cells
• ovariectomy in 4 week old mice prevents abnormal uterine growth and estrogen stimulates myometrial proliferation in ovariectomized females
• treatment with aromatase inhibitor, letrozole, for 8 weeks starting at 4 weeks of age, reduces myometrial proliferation
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• starting at 6 weeks of age, mice start to show uterine enlargement, and uterine size and weight are larger at 12 weeks of age
• treatment with rapamycin at 4 weeks of age for 8 weeks completely prevents abnormal growth in the uterus
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• at 12 weeks of age
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neoplasm
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• mice exhibit myometrial overgrowth, developing tumors consistent with leiomyomas by 24 weeks of age
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• tumors in the lungs originate from the lymphatics, suggesting that lung tumors are metastatic from the uterus
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• most females that reach 31 weeks of age or older exhibit myometrial tumors in the lungs, suggesting lymphangioleiomyomatosis
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cardiovascular system
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• 24 week old mice show appreciably larger uteri, with continued endometrial overgrowth and internal bleeding
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endocrine/exocrine glands
muscle
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• mice exhibit myometrial overgrowth, developing tumors consistent with leiomyomas by 24 weeks of age
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respiratory system
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• most females that reach 31 weeks of age or older exhibit myometrial tumors in the lungs, suggesting lymphangioleiomyomatosis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| uterine fibroid | DOID:13223 |
OMIM:150699 |
J:221228 | |
