Phenotypes Associated with This Genotype

Genotype
MGI:5642218

• Allelic Composition: Bmp7^tm1.1Dgra/Bmp7^tm1.1Dgra; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

joint inflammation ( J:221175 )

• slight increase in accumulation of F4/80+ macrophages in the synovial membrane at 4 weeks of age which increases significantly with age, indicating sinovits

osteoarthritis ( J:221175 )

• mice show articular cartilage degeneration after 8 weeks of age

skeleton

joint inflammation ( J:221175 )

• slight increase in accumulation of F4/80+ macrophages in the synovial membrane at 4 weeks of age which increases significantly with age, indicating sinovits

osteoarthritis ( J:221175 )

• mice show articular cartilage degeneration after 8 weeks of age

abnormal cartilage morphology ( J:221175 )

• loss of proteoglycan and aggrecan content in articular cartilage at 8 weeks of age which is severe at 24 weeks

abnormal joint morphology ( J:221175 )

• extensive synovial hyperplasia at 8 and 24 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:221175