Phenotypes Associated with This Genotype

Genotype
MGI:5644332

• Allelic Composition: Wfs1^tm1Yoka/Wfs1^tm1Yoka
• Genetic Background: B6J.129-Wfs1^tm1Yoka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal associative learning ( J:136108 )

♂ • mice exhibit enhanced freezing during conditioning and before the cue at the cue test in fear conditioning testing at 31 weeks of age

enhanced active avoidance behavior ( J:136108 )

♂ • mice exhibit longer escape latency and lower numbers of avoidance at the first block on day 3 in the active avoidance test, indicating diminished avoidance reaction

enhanced passive avoidance behavior ( J:136108 )

♂ • mice exhibit a longer latency to enter the other chamber in the passive avoidance test at 12 weeks of age

abnormal spatial learning ( J:136108 )

♂ • mice show increased escape latency without the change of distance traveled in the Morris water maze at 31 weeks of age

♂ • however, no abnormalities are seen in the rotarod test, hot plate test, tail flick test, marble burying test, tail suspension test, startle response, prepulse inhibition, in the open field, light-dark box, home cage activity, wheel-running and elevated plus maze

increased coping response ( J:136108 )

♂ • mice exhibit reduced immobility on the second day of the force swimming test at 9 and 12 weeks of age

abnormal social investigation ( J:136108 )

♂ • mice exhibit decreased social interaction at 9 weeks of age

digestive/alimentary system

abnormal defecation ( J:136108 )

♂ • mice have a lower number of fecal boluses during the elevated plus maze than wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Wolfram syndrome 1		DOID:0110629	OMIM:222300	J:136108