Phenotypes Associated with This Genotype

Genotype
MGI:5645239

• Allelic Composition: Dnah5^b2b2451Clo/Dnah5^b2b2451Clo
• Genetic Background: C57BL/6J-Dnah5^b2b2451Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 2451-002-LA exhibits heterotaxy with levocardia, levogastria, but right sided pancreas and malrotated gut.

growth/size/body

heterotaxia ( J:175213 )

abdominal situs ambiguus ( J:175213 )

cardiovascular system

abnormal inferior vena cava morphology ( J:175213 )

• Duplicated inferior vena

digestive/alimentary system

abnormal midgut morphology ( J:175213 )

endocrine/exocrine glands

abnormal pancreas morphology ( J:175213 )

• Right sided pancreas

hematopoietic system

abnormal spleen morphology ( J:175213 )

• Right sided spleen

immune system

abnormal spleen morphology ( J:175213 )

• Right sided spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia		DOID:9562	OMIM:PS244400	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213