Phenotypes Associated with This Genotype

Genotype
MGI:5645990

• Allelic Composition: Cdk4^tm1.1Bbd/Cdk4^tm1.1Bbd; Tg(Tyr-NRAS*Q61K)1Bee/0
• Genetic Background: FVB.Cg-Cdk4^tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:222847 )

• spontaneous development of malignant melanoma by 300 days of age in all mice

• malignant melanomas have the appearance of nodular lesions and tumors show larger and more pleomorphic nuclei, abundant cytoplasm and numerous multinucleated giant cells and low levels of Ki-67 staining

• two distinct malignant melanoma subtypes are seen: 55% of melanomas are in the deep dermis, separated from the naevus cells above by layers of collagen, while 42% of lesions encompass the subepidermal location of the naevi and appear to be expanded naevi, although cells have morphological features of malignancy

• majority of tumors are located on the back

increased incidence of tumors by UV-induction ( J:222847 )

• mice develop malignant melanoma by 200 days of age after a single neonatal UVB dose

• melanocyte migration from the follicular outer root sheath into the epidermis after neonatal UV radiation is normal

pigmentation

abnormal melanocyte proliferation ( J:222847 )

• mice develop dermal melanocyte proliferations that are similar to superficial cogenital naevi

increased melanocyte number ( J:222847 )

• neonates exhibit a higher number of dermal melanocytes

integument

skin lesions ( J:222847 )

• naevi are nearly always observed immediately beneath the epidermis in a band-like distribution, reminiscent of naevus cells, above lesions

increased cutaneous melanoma incidence ( J:222847 )

• spontaneous development of malignant melanoma by 300 days of age in all mice

• malignant melanomas have the appearance of nodular lesions and tumors show larger and more pleomorphic nuclei, abundant cytoplasm and numerous multinucleated giant cells and low levels of Ki-67 staining

• two distinct malignant melanoma subtypes are seen: 55% of melanomas are in the deep dermis, separated from the naevus cells above by layers of collagen, while 42% of lesions encompass the subepidermal location of the naevi and appear to be expanded naevi, although cells have morphological features of malignancy

• majority of tumors are located on the back

cellular

abnormal melanocyte proliferation ( J:222847 )

• mice develop dermal melanocyte proliferations that are similar to superficial cogenital naevi

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:222847