Phenotypes Associated with This Genotype

Genotype
MGI:5647920

• Allelic Composition: Tg(Tff3-Tmem207)1Tamo/0
• Genetic Background: C57BL/6-Tg(Tff3-Tmem207)1Tamo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin tumor incidence ( J:217436 )

• about 14% of females and 13% of males at 6-12 months of age develop spontaneous intradermal tumors with features resembling those of various human cutaneous adnexal tumors with high incidence

• all tumors are in the subcutaneous axilla, inguinal region, or back

• almost all tumors exhibit partial differentiation into sweat gland units

• all tumors form intradermal masses that usually resemble human cylindroma or spiradenoma and which are characterized by mosaic-like tumor nests of basaloid cells

• some tumors partially exhibit apocrine, follicular, and sebaceous differentiation

increased trichoepithelioma incidence ( J:217436 )

• some tumors exhibit a partial trichoepithelioma morphology

increased carcinoma incidence ( J:217436 )

• several tumors resemble human adenoid cystic carcinoma with tubular and cribriform patterns

• in the cutaneous adnexal tumors, adenoid cystic carcinoma-like malignant tumors and malignant tumors with features of salivary-duct type adenocarcinoma are seen

integument

increased skin tumor incidence ( J:217436 )

• about 14% of females and 13% of males at 6-12 months of age develop spontaneous intradermal tumors with features resembling those of various human cutaneous adnexal tumors with high incidence

• all tumors are in the subcutaneous axilla, inguinal region, or back

• almost all tumors exhibit partial differentiation into sweat gland units

• all tumors form intradermal masses that usually resemble human cylindroma or spiradenoma and which are characterized by mosaic-like tumor nests of basaloid cells

• some tumors partially exhibit apocrine, follicular, and sebaceous differentiation

increased trichoepithelioma incidence ( J:217436 )

• some tumors exhibit a partial trichoepithelioma morphology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epidermal appendage tumor		DOID:2433		J:217436