Phenotypes Associated with This Genotype

Genotype
MGI:5659881

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Stk11^tm1.1Rdp/Stk11^tm1.2Rdp
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:124682 )

• mice inoculated with an adenovirus expressing cre recombinase (ad-cre) by inhalation have a mean survival of 9 weeks after ad-cre inoculation

neoplasm

increased metastatic potential ( J:124682 )

• regional lymph-node metastases and axial skeleton metastases are seen in 61% of ad-cre inoculated mice

increased lung tumor incidence ( J:124682 )

• mice inoculated with ad-cre develop lung tumors; tumor burden is increased at early time points and larger lesions at later time points are seen than in single Kras mutants

increased lung adenocarcinoma incidence ( J:124682 )

• adenocarcinoma is seen in all metastatic lesions

increased lung large cell carcinoma incidence ( J:124682 )

• 2 of 27 ad-cre treated mice show large cell carcinoma

increased lung squamous cell carcinoma incidence ( J:124682 )

• 56% of ad-cre treated mice develop squamous cell carcinomas (SCCs) or adenosquamous carcinomas

• squamous tumors do not express pro-surfactant protein, but express pan-keratin and p63, markers of SCC

respiratory system

increased lung tumor incidence ( J:124682 )

• mice inoculated with ad-cre develop lung tumors; tumor burden is increased at early time points and larger lesions at later time points are seen than in single Kras mutants

increased lung adenocarcinoma incidence ( J:124682 )

• adenocarcinoma is seen in all metastatic lesions

increased lung large cell carcinoma incidence ( J:124682 )

• 2 of 27 ad-cre treated mice show large cell carcinoma

increased lung squamous cell carcinoma incidence ( J:124682 )

• 56% of ad-cre treated mice develop squamous cell carcinomas (SCCs) or adenosquamous carcinomas

• squamous tumors do not express pro-surfactant protein, but express pan-keratin and p63, markers of SCC

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung non-small cell carcinoma		DOID:3908		J:124682